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Holy Hand Grenade 

1) Monty Python: A hand grenade forged to smite the powers of evil. Instructions: Pull pin, count to three, throw.

2) Worms: MOST POWERFUL WEAPON EVER. Or at least the coolest. A parody of the Monty Python weapon, the holy hand grenade is an awesome weapon which shouldn't be reckoned with.
1)And Saint Attila raised the hand grenade up on high,
saying, 'Oh, Lord, bless this thy hand grenade that with it thou
mayest blow thy enemies to tiny bits, in thy mercy.' And the Lord
did grin, and people did feast upon the lambs, and sloths, and
carp, and anchovies, and orangutans, and breakfast cereals, and
fruit bats, and large...

2) wURmz_Masta: i totly pwned u wit tht holy hand grenade. haha
Holy Hand Grenade by Lyrax February 25, 2005

take the grenade 

To sacrafice yourself by feigning interest in the hot girl's/guy's fat/ugly/annoying friend. Generally done while going out with a group of people, as it would be senseless to fall on the grenade solo.

see also fall on the grenade, jump on the grenade, sit on the grenade.
Rupert: Thanks for taking the grenade last night, man. It was totally sweet hooking up with that really hot girl. How was hooking up with her ugly friend?"

Cornelius: Not so bad once I got the brown paper bag over her head.
take the grenade by cosmo October 8, 2004

Southern Maryland Hand Grenade 

term referring to 10 oz Budweiser cans in Southern Maryland, all can beer can be referred to as such but 10 oz bud is the preferred version
The party seemed over until Buddy showed up with a case of Southern Maryland Hand Grenades.

dave grenade 

A grenade in Call of Duty 4 or Halo 3 that bounces back at the thrower and usually kills him.
"Oh man I just threw a Dave Grenade and it killed me"
dave grenade by Viperish Fall February 23, 2008

redneck grenade 

The improper disposal of solid human waste when camping whereby the producer of said waste tosses it into the camp site of unsuspecting fellow campers.
When camping along the Duck River in Tennessee, Billy Bob pooped on a plate and tossed the redneck grenade like a frisbee onto the river bank where canoers later discovered it in horror.
redneck grenade by RedneckBilly April 29, 2010

party grenade 

A person who shows up at a party and explodes with un social acts.
That drunk Asian guy just destroyed your bathroom! He is a big time Party Grenade!
party grenade by Gord Jorgensen August 6, 2009