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To be pussy whipped or handcuffed by the muff.
Jannette- "Did Liam stay in with his wife again?"
Nathaniel- "Ya, he's muffed."
Muffed by JoyRider August 26, 2009
Mikey- Dude did you see John at the party last night?

Tyler- No why?

Mikey- He was muffed!

Tyler- Damn!
muffed by Lil Beetch May 26, 2011
This is when a woman has been given pleasure by her partner through oral sex.
muffed by John Tong April 22, 2005
when a person gets knocked to the head with an extra heavy blow(also see murked).
I muffed him with my bat after I found out he stole my stuff.
muffed by antoinette fleming February 19, 2003
"Man, that girl is muffed!"
muffed by Ricky Perez October 21, 2003
To completely screw up or to fail miserably.
Essentially another form of "messed up".
Dude, you totally Muffed out with your girl.

My man, you're totally Muffing Out right now.
Muffed by IHaveASmallPP August 13, 2018