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Fatal Familial Insomnia 

An extreme, ultra-rare form of insomnia that is downright terrifying to even think of. First identified in the mid-18th century, fatal familial insomnia (FFI) is a progressive disease that makes it physically impossible for a person to sleep.

The symptoms of FFI can be divided into several "Stages" which are as follows:

Stage 1: Habitual sleepiness/drowsiness
Stage 2: Hallucinations

Stage 3: Memory loss/dementia

Stage 4: Coma, then death

Fatal familial insomnia is not curable, and there are no methods of slowing it down that medical experts are aware of. One might think that sleeping pills are a good idea, but that couldn't be farther from the truth; remember the main symptom is that you CANNOT SLEEP no matter what. Sleeping pills actually make it progress quicker. The disease generally kills in less than three years, and in some cases even less than a year. However, there have been anomalous cases where people have lived for five years or more with the disease.
Fatal Familial Insomnia is a terrifying disease. The initial symptoms before you start to (literally) lose your mind last just long enough for you to realize that it's happening, and the fact that it cannot be stopped once it starts REALLY ramps up the panic that ensues.
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fatal familial insomnia 

A scary-ass incurable condition cause by none other than prions. Worst part it can spread to other people via contaminated surgical equipment.
move over cancer fatal familial insomnia is the new disease to be scared of.

Repetitive Familiarity Amnesia 

The inability to remember if you did something you do every day.
Every morning when you leave the house, you push the button on the garage door remote closing the garage door. Then 10 minutes later, you can’t recall if you closed the garage door because you do the exact same action at the exact same time every morning, so they all blend together and you couldn’t tell if your memory was from that morning or any of the previous mornings where you went through the same motions like you have countless times before. You just experienced Repetitive Familiarity Amnesia.

gettin' too familiar 

Dat nigga gettin' too familiar, Imma have to whip his ass.
gettin' too familiar by Dom the Bomb February 20, 2008

societal familiarity disorder (SFD) 

When two people spend a lot of time together and begin to develop feelings for each other. But they actually are just assuming society's view on relationships. That people are suppose to be in pairs. So two good friends think they're in a romantic relationship.
John and Jane are both unemployed, so they have a lot of time to spend together. They start getting feelings that they mistaken as romance. They start really dating, get jobs and realize they were suffering from societal familiarity disorder (SFD)!

I owe you an apology. I was not familiar with your game 

A fraze once made popular by NBA Legend Shaquille O'Neil reacting to a surprisingly good performance by a current NBA Player that he never thought was able to put on the court, undermining his class up until this very point in time.

This term is now commonly used to describing a situation in which an individual (mostly male) acknowledges the fact that a (female) has been attractive and he just never noticed or was blind to this fact for other reasons, leading him to apologize using the infamous inside joke.
1. Shaq: Christian Wood I wan't to apologize, I wasn't familiar with your game and-
Wood: Aw man, you're a casual!

2. Dude: Gyatt, Sandra that booty phaaat. You been hitting the Gym lately?
Sandra: What? My booty been fat ever since, where have you been?

Dude: Oh okay, I see you now though. I owe you an apology. I was not familiar with your game.

Pai de familia

Pai de Família (Portuguese for “family man”) is a man from a Brazilian gay porn video. Pai de Família’s real name remains unknown, but he’s often called Jailson Mendes, as he’s credited in the movie. Pai de Família’s main claim to fame is, well, taking it in the ass.
Pai de familia is the most famous meme in brazil