John Saunders went way too hard for way too long but hasnt touched drugs in 10 years. Even after such a long period of sobriety he shows signs of serious brain damage and as such is permafried
by rocketdogz September 21, 2010

by XxbertxX September 1, 2006

Getting baked too often to where you have the effects without smoking, makes you feel stupid and lost at times
by Ace-_-420 August 5, 2011

Where you smoke so much weed, you feel, even when youre not stoned, a feeling of physical and mental exhaustion.
by mitch connor II September 10, 2011

smoking so much weed that you are known to have S.R.D. (stupid retarded disorder). also known as "William Fisher."
that kid is permafried!
by willie wonka520 July 7, 2008

When youve done too many drugs in a short amount of time youre permanently fucked up/ retarded
Also known as a Matthew Ramo.
Also known as a Matthew Ramo.
by Fanxis August 16, 2017

When someone has done so much dope in their life that they end up in a perpetual state of slowness and stupidity
by numbnuts33 March 25, 2025
