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An abbreviated way to ask the question, "May I Help You?". Typically used by counter workers in the fast food industry, but not exclusively by them.
Good morning Wendy, welcome to McDonalds, melpyou?
melpyou by Li XiaoLong July 6, 2016
Related Words

Melpo Mene 

an independent band formed and headed by musician Erik Mattiasson from Stockholm, Sweden.

Discography:
-Holes (2004)
-Bring the Lions Out (2008)
-Behind the Trees (2012)

The single "I Adore You" (from "Bring Lions Out"), was used in a 2008 Volvo car commercial.
- Can you name all nine muses?
- Well when Melpo Mene started to release soundtracks for the motion movie where all muses were named, i learnt all of them
Melpo Mene by annalotte August 15, 2012
Short for "May I Help You".
Subway Associate: "Melpya?"
Subway Patron: "Yes, I'd like a 6-inch Cold Cut with Pepper Jack Cheese, toasted please."
Melpya by EVGNick May 27, 2010

Melphomene Projects 

One of the most dangerous housing developments in the U.S.

The Melpomene Project was constructed in 1964. The site was once made up of single and multi-family houses; by the late 1950s the city declared them slums which paved the way for the project. It is the youngest surviving housing project in New Orleans. In 2004-05, half of the development was demolished and renovated after failing to meet the Housing Authority of New Orleans' economic viability guidelines. Subsequently, the demolition of the other half has been put on hold. The complex is commonly referred to be the nickname "Melph".
Man 1 - Aye, did you hear about that shootout in that secondline Uptown?

Man 2 - Yep, it was right by the Melphomene Projects.
Melphomene Projects by Nola-Boy March 29, 2010

Melphomene 

(adj.) Someone who has a melodious voice.

(n.) A group of singers; Singerhood
You’re such a Melphomene.

Have you heard of the Melphomene Singerhood?
Melphomene by wenk wonk October 24, 2019
Melphamine projects in New Orleans.
"From the Mac, to the Melph, to the Calio"-UNLV
Melph by UptownSoulja February 5, 2005