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Something that is way cool. Too big to be described as merely "awesome". Opposite of micro.
Did you see that movie? That shit's way macro.
Macro by UrbanFool1234555 December 9, 2008
1. (N proper) One who has sex with many many women, preying on them generally when they are exceptionally drunk. These women are usually students. The name developed from the term "macrophage"; a human cell which devours any form of foreign material without discrimination. It was given to a medical student at Glasgow after a streak of returning to women's homes after an evening in what was called his "Sex for Shelter" campaign, since said medical student had nowhere to live.

2. (V) The act of chatting up random drunk women and taking them home from a nightclub. Often, this requires many rejections or false starts before a women is successfully "phagocytosed".
1. Check out Macro with that fat bird.

2. I'm gonna be Macroin it up in the Hive tonight!
Macro by Macrophage June 12, 2006
Someone who carries the obsessive compulsive disorder of Not Shutting Up (NSU). Believes to be a an all star human that has the highest of intelligence but is often laughed at for his lack of common sense and true idiocy. If he would be quiet once in awhile, people make enjoy his company.
Dude, that guy has way too much macro going on.
macro by Peteyboy007 March 27, 2008
A large Hoe, or a hoe with large breasts or a large ass.
" Yo Mike, check them breasts on that macro."
Macro by Gerald January 12, 2005
Used to describe something that is incredibly crappy, somewhat purposeless and usually is instantaneously obsolete. Somewhat derogatory.

Origin: A video game controller with a "Macro" button on it, which usually causes said game to cease function.
"Dude, this controller has a button that freezes the game."
"That's so Macro!"
"Yeah, there's no excuse for that."
Macro by Adam Laughlin December 27, 2004
1. The opposite of micro. When referencing an idea: large, high scientific, philosophical, or spiritual. Outside of the average everyday meaning or functional purpose.
2. Referencing something a layer deeper than is the norm, esp in a jocular way.
That’s too macro, dude; lay it out more plainly.

Pass me that square of sequestered carbon molecules”

“It’s called plywood. Stop being so macro.”
Macro by Treebeard May 20, 2018