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The one movie that singlehandedly destroyed everyone’s ability to feel things.
Person 1: did you see Endgame?

Person 2: yeah, man..I literally can’t feel anything now
Endgame by ThrowYourMbackOut April 29, 2019
To make it to the last level of a game. To be considered at the peak of your game. To be the best/elite/powerful. Best and/or powerful items come from the EndGame.
In regards to MMO's, making it to EndGame is basically defeating the most difficult content provided. Player1, "I've never seen a sword with those high stats, you must be at EndGame".

Can also be used comparitively to career success.
EndGame by GIZAK September 22, 2005
The desirable outsome of a one or a series of acts.
Charlie pokes suspected bee hive.
Mac: Ok, alright, don't poke at it, just get it safely down into the box.
Dennis: Dude, you're going to aggitate the bees.
Charlie: Well, I'm fine with the bees, it's the honey I don't want to aggitate.
Mac: Is that your endgame here, honey?
Charlie: Yea I figure we keep the hive in the basement and we'll always have honey.
Dennis: We'll always have bees is what we'll always have!
Charlie: Whoa!
Dennis: what?
Charlie: I think I just say a wasp.
Dennis: That was a wasp.
Charlie: Did you see that, it looked like a wasp right?
Mac: Is this wasp nest?
Charlie: This is a wasp nest.
Mac: I'm out, I'm out.
Dennis: Yea, I don't want to tango with a bunch of wasps.
Charlie: Hey! Do wasps make honey?
Dennis: No, wasps do not make honey.
Charlie: Alright. Well I'm gonna check it out anyway, there could be something delicious in here that wasps do make, and I want that.
endgame by Sir Wilhelm Schnotz August 22, 2010
1) The final stage of any dramatic event.
2) The final stage of a chess game, usually after a significant reduction in material.
Jack slept with a dirty woman which forced him into the endgame of his already pathetic life.
endgame by Zen January 3, 2007
bro have you seen endgame yet?

yes it has endgame spoilers, don't watch it.
endgame by um42069420 May 16, 2019
Can mean a couple of things:

The term coined in a TV Show when the season or series reaches its dramatic climax or penultimate finale such as a master plan coming to fruition. The Endgame is usually the most anticipated part of a tv show, it's achieved at the end of a season/story arc and is what the episodes prior has been building up to and is often teased throught, this is known as playing The Long Game.

Endgame can also refer to a ship in a TV Show, so the relationship a character will end up with at the end of the series.
Stelena from TVD is so endgame <3333!!!
Endgame by RobotWizard December 20, 2017