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Evil Dead Syndrome 

When a media franchise's sequels either stray wildly from their original tone (usually in the direction of "wackiness"), usually by giving increasing importance to smaller aspects of the earlier works.

Named for Sam Raimi's "Evil Dead" series, in which the first film was a serious horror movie with minor humorous bits, the second film "Evil Dead II" upped the ante, including a chainsaw-hand, culminating in the third film "Army of Darkness", which featured far too many insane (and awesome) items to begin to list.

Note that Evil Dead Syndrome is not necessarily a bad thing, and is not limited to films.
Paul: "Remember when The Fast & The Furious was about street racing and not about pulling a 20-tonne bank vault through a crowded city?"
Vin: "No."
Paul: "Me neither."

Pierce: "So in Saints Row IV, the boss becomes the President of the USA and fights an alien invasion."
Johnny: "I thought Saints Row was about gangsters?"
Pierce: "Don't be ridiculous!"

"Saints Row The Third drinks 'wackazade' from a clown shoe. This is a trilogy progression we academics call Evil Dead Syndrome." - Yahtzee Crowshaw
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Sandy Vag Syndrome

A condition which results in constant irritability. The most common symptoms of this disease include a predisposition towards being easily offended, hurt, with an affinity for holding grudges, and general discomfort for the sufferer and everyone within earshot
Amer is so easily offended, that dude has a serious case of Sandy Vag Syndrome.
Sandy Vag Syndrome by HeyZeusChristo September 24, 2014

Perpetual Positivity Syndrome

A term coined by author Jeff Brown, PPS (Perpetual Positivity Syndrome) is one of the most common obstructions to awakening on the healing path. Defined as ‘the addictive need to default to positivity under any and all circumstances’, it prevents a maturation in the deep within because sufferers refuse to be present for all that is. Symptoms include a constant need to find the light in every situation, a tendency to forget or ‘rise above’ the negative aspects of their partners, an inability to fully support and hold the space for other’s suffering, and a turning away from the growth work demanded by life's challenges. Instead of forging a grounded, discerning positivity in the heart of all that is, they jump to the light, while averting the shadows that inform it. They reactively bliss-trip, when lessons are waiting in the wings to be learned. Those who suffer with PPS are often of the illusory view that they had perfect childhoods or that they have moved beyond the shadow, but they are sadly mistaken. If anything, their obsessive clinging to the ‘positive’ is rooted in their unresolved emotional material: pain and anger that will only come back to haunt them. At the end of the day (when the darkness settles in…), there can be no light without shadow. And no substitute for hard-earned transformation.
I eventually owned that I had Perpetual Positivity Syndrome, and I finally began to heal and grow.

dead fish syndrome 

When you’re tryna get it in with your girl but she’s just laying there like rigor mortis has set in. Not a single movement or sound escapes her body. Usually followed by “I swear it was good babe” when it in fact, was not good babe
“I was ‘Netflix and chilling’ with Becky last weekend and that bitch had dead fish syndrome.”
dead fish syndrome by Asdfghhh April 23, 2018

baby boy syndrome 

A grown man that’s still attached to his mother’s nipple. Usually totally dependent on his mom. This adult male lives at home and / or is unable to make decisions without his mother’s approval.
I need a real man, not someone with baby boy syndrome!
baby boy syndrome by ChamberGirl February 6, 2018

milk carton syndrome 

A compulsive habit of collecting milk cartons and filling rooms up to the ceiling with them.
Poor fellow had a very large house with only one room to live in, thanks to a life long disability called milk carton syndrome.

D.Va Syndrome 

D.Va Syndrome (pronounced Diva Syndrome) is an illness unique to the players of overwatch, specifically to those who play the character "D.Va". The main and most noticeable symptom of this syndrome is as follows. Whenever the player notices they are below half HP (critical hp) a trigger activates in their brain, forcing them to use every single ability at the same time and fly directly into the enemy team. Other common symptoms can be: using bomb without boosters and standing at the back of the team using D.Va as a sniper.
"Devin just flew into the enemy team on 10 HP, he must have D.Va Syndrome"
D.Va Syndrome by Snish_ June 6, 2021