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A sarcastic remark to an unamusing statment, comment, joke, or question. Most people when saying "Yo Sick" tend to point both arms in the direction of the person who has made the idiotic comment. It is also custom to add the person's name at the end of the "Yo Sick"
Yo Sick: Adjective describing someone unamusing

Person 1: Stupid comment nobody cares about
Person 2: Yooo sick

Eckel: Guys the broncons are going to win the superbowl and the Uconn huskies are going to win the NCAA national championship
Everyone in the General Area: Yoooo Sick Eckel

Austin Allen: Whats up Davey Burgers
Eckel: Yooo sick Don
Yo Sick by Dan Archer July 6, 2008
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Wicked Sick 

The skill level after GOD-LIKE in Unreal Tournament, only achievable by a true champ of the game.
bob killed robert with flak cannon - WICKED SICK!!
Wicked Sick by Anonymous February 6, 2003
Related Words

fully sick 

FULLY SICK;

A wog/lebbo expression that means excellent or very
good...also can be used to play out wogs/lebs.... :)
Check out my vl boyz,its fully sick
Aaay guys look at that maria walking down the street,she looks fully sick.
That car looks fully sik habib...
fully sick by nathan308 November 21, 2006

mini sick 

that small sick that sometimes comes up when you burp leaving the taste of your last meal in your mouth before being swallowed back down!
BURP! Oh dear, just made mini sick in my mouth. Tastes like the chicken I had for dinner!
mini sick by Doctor Tripod February 21, 2009

duck sick 

an oral technique preformed by a dyslexic prostitute
i duck sick for five dollars
duck sick by Josh Posh December 7, 2009

Aright Sick 

A sarcastic way of saying "ok cool" used usually when a person is mad or disapointed

" you had sex with my ex girlfriend? aright sick.. "

" You cant lend me five dollars to buy booze? aright sick.."
Aright Sick by Yofray January 21, 2009

Dead. Or Sick. I forget. 

Used on a messageboard when someone asks where a particular poster is, after an absence from the forum.

Origin is from a line Krusty speaks on The Simpsons when Bart Simpson asks him where is Sideshow Mel.
Metalhammer User 1: What happened to Vim Fuego?
Metalhammer User 2: Dead. Or sick. I forget.
Dead. Or Sick. I forget. by Lugs-o October 16, 2004