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The only correct response to "Can I ask you a question?" besides "You just did."
"Can I ask you a question?"
"Shoot."
shoot by Lairor December 9, 2004
Shoot, I lost the lotto by 1 number!
SHOOT by AC December 7, 2003
go ahead and ask your question
girl: can I ask you a question

guy: shoot
Shoot by someone April 4, 2005
Bob: Want to hear a joke?
Joe: Shoot
shoot by Jerrick Rodriguez March 19, 2007
As George Carlin once said its just...

"Shit, with two o's"
Aww shoot i forgot we had the physics test
shoot by Me,I,Yo October 14, 2009
1. A means of taking drugs
2. To fire a gun or other projectile weapon
3. A light curse word
1. Johnny had to shoot up when he was gettin low.
2. Johnny decided to shoot his dog.
3. Shoot, the damn dog lived. Johnny has bad aim.