How people who are too lazy to add a single apostrophe to a word, spell the phrase, "What's up?" (What-is-up?).
Man: Hey man! Whats up! I'm so lazy that I decided to leave the apostrophe out of "what's", that way I can conserve more energy. You know, because I oppose global warming and all that.
Short-hand for the word floccinaucinihilipilification, meaning the estimation of something as valueless (encountered mainly as an example of one of the longest words in the English language).