To be pregnant.
It was very embarrssing for Kevin when he got Peggy up the duff, but it served him right for trying to save money by using a flak jacket.
by Dunky Oggins December 7, 2003
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Did you hear?! Babs finally has one 'Up The Duff'! They've been trying so hard! I'm sooo happy for her!!!
by talk2me-JCH2 March 15, 2022
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An expression of great misfortune, expanded from it's original meaning, to be pregnant. The expansion is due to the expression often being the unfortunate case of the pregnancy being untimely and unpredicted.
"When they find all the coke in Mark's desk, he's gonna be sooooo up the duff!"

"Shit, I've got 2 flats and only 5 minutes to get the airport!"
"You are up the duff mate"
by Jack Nicholson February 3, 2006
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You’re all idiots it means anal sex
She takes it up the duff, because she loves anal
by TheDuffQueen November 6, 2017
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A person who was a duff in their past and is now a hot glown up masterpiece
Guy 1: Damn heathers a come up duff!
Guy 2: Yah she used to be really ugly but now I really wanna date her
by Em's definitions August 14, 2017
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