Uncle Floyd Share definition Flag Occurs when a man has hemorrhoids and wipes blood from his anus. Compare to a woman's menstrual cycle and "Aunt Flo". I needed a maxi-pad after that week-long cruise. Uncle Floyd came to visit unexpectedly. Uncle Floyd by Spanishjohnny99 March 28, 2011 0 0 Get merch Get the Uncle Floyd mug. Buy Now — $32.95 See more merch