twinkie bitch Share definition Flag a gay person; a fagget. Someone who acts gay or is gay. t.b. is short for twinkie bitch 1) that guy wearing a dress is a Twinkie Bitch. 2) that TB just touched my ass. twinkie bitch by James Gonzales January 5, 2008 0 0 Get merch Get the twinkie bitch mug. Buy Now — $32.95 See more merch