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More commonly referred to as marijuana.

The term twindle refers to the dried leaves and flowers of female Cannibus plants. Twindle is used to describe the fine filaments of these combined items. The word twindle can also be used to describe the feeling that you would have upon smoking said substance. The feeling of pure pleasure as you can actually feel your sperm count lower.
Ev95: "Yo, you want me to pack you some?"

Hen69: "Pack some what??"

FedNeg: "Well, some Twindle, of course."

Hen69: "Indeed. Pack that shite, neg."
twindle by The_Messiah July 15, 2009
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The motion a spider makes upon rapidly encasing a bug in its web filament.
A stinkbug flew off the elbowbush but got stuck in the huge web. It struggled to get free but was twindled up by the spider at lightning speed.
twindle by Cromes March 26, 2009
to feel an emotion to its fullest extent. to express an emotion with great exaggeration.
Conor69: i even understood it even though you are spelling Jaeger incorrectly, Chaz.
chaz20: I twindle in delight of your exceptionally keen eye, Conor. But, for safety purposes I must provide due warning...
chaz20: I am the Jagernaut, bitch.
twindle by mastashakezzzzz May 30, 2006
After wrapping the package with twine, Mom asked me to sweep up the twindles from the floor.
twindle by Tyler F. March 7, 2007

twindle the twine 

So, Adrian, did you twindle the twine last night?
twindle the twine by AIDS Donkey September 1, 2012

Twinkle-Talk 

It's when you "talk" to another "twinkle-talker" by combining your eyelid movements and Morse code to send a message from a person to another while no soul can notice or use this communication method against them. This code-based messaging technique uses Morse Code, a series of short and long signals called "dots" and "dashes". So a quick wink is a morse code "dot", and a "dash" is done by a winking slowly and longer. All you have to do is learn morse code. And with this method you can actually "shine" for real, a form of concrete telepathy. The distance? Who knows? Got binoculars?
I was twinkle-talking my lawyer and nobody knew what we were talking about. The prisoner twinkle talked to his friend in jail and got his message across flawless.
Twinkle-Talk by Ascot1111 December 22, 2022

twinkle cave 

Quite simply, a nice term for the vagina. Initially coined by English comedian Jimmy Carr.
She was so excited you could swim into her twinkle cave with ease.
twinkle cave by olycat April 5, 2013