Essentially damnation, or the act of being condemned to Hell. Can also be used as a noun for Hell itself.
"That bitch Satan is sure gonna get the big red one, or my name ain't Bernard God."

"Off you go, Hitler! See you in the big red one!"
by Horace Wimp November 8, 2006
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The biggest slag you know. (Big red One - Bus in london - Everyone rides)
Oh, i know that gorl, shes a big red one
by Anon-1 July 4, 2009
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