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To follow in example of Nikki Sixx, "Sixx'n" refers to overdosing, being revived in an ambulance, escaping the hospital, and going home only to overdose again. When used as a verb in casual conversation, "Syxx'n" does not necessarily have to refer to heroine use, but can describe being under the influence of any substance, and getting into trouble.
Dude, I'm totally syxx'n it up this weekend.
syxx'n by Sic6Sixx August 15, 2011
Related Words

Two-Syxx 

“Two-Syxx” is a simple gang cipher used by a small local street gang in Detroit known as the Hyena Crips, the cipher is “2+6=8”, in the Hyena Crips street gang the number “8” is widely recognized to represent the 8th letter of an alphabet “H” for “Hyenas”, “Two-Syxx” is used by Hyena members to refer to themselves as Hyenas.
“Two-Syxx Gang shut down 4 parties last summer, them boyz too active”
Two-Syxx by 313forLife September 16, 2025