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To forget about someone or something, to let go, to get over it, to move on.
As in Mariah Carey's song:

"I gotta shake it off
Cause the loving ain’t the same
And you keep on playing games
Like you know I’m here to stay
I gotta shake it off
Just like the Calgon commercial
I really gotta get up outta here
And go somewhere
I gotta shake it off
Gotta make that move
Find somebody who
Appreciates all the love I give
Boy I gotta shake you off
Gotta do what’s best for me
Baby and that means I gotta
Shake it off"
by StefB86 May 18, 2006
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Jun 22 Word of the Day
Taken in the contest of the song Baby's Got Back by Sir-Mix-Alot he is referring to Florence Griffith Joyner a track athlete in the 1988 Olympics who defiantly fits all the other descriptions of what he likes in women mentioned in that song. Not some soda why on earth would you want to keep your women like a soda anyway?
You can have them bimbos,
I'll keep my women like Flo Jo
by Pdough May 15, 2006
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3
After a male urinates, he doesn't wipe like a female would. Instead he holds onto his genitalia and "shakes" it, so as to dry off.
He had to (shake it off) so he could put it in his pants.

*glancing around stupidly at your friends, miming the shaking off* "(SHAKE IT OFF)".

~(shake it off) can also be used as a dumb immature joke, as seen in example number 2~
by -S July 08, 2005
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