psylophile Share definition Flag one who enjoys the consumption of shrooms and/or their psychoactive compound psilocybin. "Alyx realy enjoys the consumption of shrooms and/or their psychoactive compound psilocybin. she is such a psylophile." psylophile by (sic)fuck March 28, 2007 0 0 Get merch Get the psylophile mug. Buy Now — $32.95 See more merch