A name that you give to puppies that crap all over the house no matter how hard you try to housebreak them.
I rescued two little poopies from the animal shelter. My carpets will never be the same....
by Hackermom December 11, 2005
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1) Being in a bad mood, irritable, a generally unplesant attitude.

"Jane is very poopies right now"

"Are you poopies?"
by unknown1721 January 11, 2006
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poopie is stinky and sometimes large in size.
i went for a poopie today. it smelled really bad.
by KeeKee656575744 November 14, 2006
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Noun: To become ill, but not for an obvious reason. Such as your girlfriend owns your ass, and since you are pissed about that you become "poopie".
Mike: Dude, what is up with Lou?
Patrick: Shit dude, he has been poopie all day about his wife and how she is spanking him about the laundry not being done.
by Themastercylinder February 28, 2006
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Poopie is part of the "Poopie and Explodie" duo from a Ren and Stimpy Cartoon.
Explodie: "I have to throw up now, Poopie!"
by Ross January 15, 2004
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