Paroxysm Share definition Flag a sudden, severe attack of the symptoms of a disease, usually recurring periodically; a sudden outburst of emotion In The Sea-Wolf by Jack London, Wolf Larsen's paroxysms lead to his eventual death. Paroxysm by mephisto97 July 24, 2010 0 0 Get merch Get the Paroxysm mug. Buy Now — $32.95 See more merch