This is a surgical procedure to remove the nerve that runs between the eyeball and the asshole, with a desired result of improving the shitty outlook of the patient
Jane was a real "Debby Downer" until she had an Optorectomy last week and now she's a regular Pollyanna.
A hardo is a person who tries extremely hard at everything. Most times a hardo will try very hard at things that do not require excessive effort. For example, sports practices, gym class, etc.
Wow did you see Jack at practice today? What a hardo!