Stands for, "Oh, my fucking God, will you shut the fuck up?" When someone is babbling on and on and you're sick and tired of it.
Friend 1: "Did you know that blah blah blah blah blah blah blah blah blah blah blah?"
Friend 2: "omfgwystfu"
Friend 2: "omfgwystfu"
by xxylvii February 20, 2021
Get the omfgwystfumug.