mexi-puff Share definition Flag A frizzed out hairdo, like an afro, but on a Mexican. Yo, your man Eric needs to use some hair gel to tone down that mexi-puff of his. mexi-puff by Liz Whiz February 25, 2009 0 0 Get merch Get the mexi-puff mug. Buy Now — $32.95 See more merch