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lose your marbles

Lose your marbles = lose one's mind, insanity, person who does not have common sense/wits.
"Lose your marbles"
I knew she'd eventually lose her marbles = I knew she'd eventually lose her common sense/rational mind

Have you lost your marbles?. Means the same as "Have you lost your mind"?
by DAlmighty May 12, 2009
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