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Literally meaning yes. A ghetto slang term derived from 'for sure, my nigger'.

Also. Fo' shizzle my nizzle.
Also. Fo' shizzle mah nizzle.
by Lexicon Master September 15, 2003
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2
Idiomatically translated: This is for sure-as in one would know this fact to be true.

Literally translated: FOR SURE MY NIG*A
TYRONE: Did you pass that difficult biology class at Harvard last semester?
KEYSHAWN: "fo shizzle my nizzo"--- Of course I passed the class with flying colors only to affirm my position on the Dean's List. How could you make such a ridiculous inquiry as to question my unlimited abilities?
by \'YO MAMA\' September 04, 2003
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3
A dazzled up way of saying "for sure my nigger" Originally used by african americans such as: Snoop Dogg and Jay-Z but over-taken by wiggers such as Justin Timberlake because of it's easy-speaking nature.
"Fo shizzle my nizzo! Dirty Pop sure was a great N*Sync hit!"
by Kristen December 01, 2003
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5
I guess its short for "Fo shizzle my nizzle" which is a phrase coined by rapper Snoop Dogg, his way of saying "For sure my nigga"

:wiggle:
by apathy September 12, 2003
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7
Explicit. An ebonic version of the phrase: For sure, my nigger. Used as a means of assent or agreement with a trusted companion.
Negro 1: Yo' wanna party wit' me?
Negro 2: Fo shizzle my nizzo
by Azmodeus September 17, 2003
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