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A more derogatory term of the word, doofus.

One who is stupid beyond all belief.
It was Jordan's 21st the other day and she was being such a duffas.
Duffas by Magic show November 30, 2010
Related Words
Duffsex is where erectile dysfunction, performance anxiety or alcohol intoxication leads to the disappointing premature discontinuation of intercourse without climax by either participant.
guy1: dude, did u hear hadi got laid last night? with this bear fit irish chick innit!
guy2: yea but it was duffsex... how embarrasing. shame about the bird too, she's zhaofit.
guy1: no way! is he gay?
guy2: no think he was just too wasted innit and such.
guy1: well, at least he didn't have to pay this time.
Duffsex by chairmanzhao May 31, 2010
Refers to someone who is extraordinarily dumb, as exhibited by extraordinarily bad choices.
Duffus

It just refers to someone who is exraordinarily dumb. A derivative of "dumbfucks" from the latin dummass frickinious idiotus.

Dude was a total duffus and used gasoline to start his charcoal for the picnic! Hence the fire department and paramedics
duffus by DustyDude June 3, 2015
Someone who jokes around a lot. Someone who tends to act a fool, yet in a humorous way. Everyone loves them a good ol' Duffa!

And there is also "Duffery", which is the proper word to describe the actions a Duffa takes!!
Sam: so, I bit my cat the other day.

Ryan: you silly Duffa.

Sam: I was just bored, bro.

Ryan: what's with all this duffery?!
Duffa by Cay Breezyy's January 23, 2012
A Fat girl or group of fat girls who cockblock. Slang on the word duff. Originated in NC
I was gonna smash but shawty's herd of Duffalo trampled the club
Duffalo by STMONEY May 23, 2007