bruffin Share definition Flag A pastry that is a brownie + muffin combination. Prepared by cooking brownie mix in muffin tins, so they are muffin shaped brownies. Best served upside-down. Want me to bring the batch of bruffins I just whipped up over for dessert? bruffin by zenni May 4, 2009 0 0 Get merch Get the bruffin mug. Buy Now — $32.95 See more merch