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1: to irritate so that it makes one's blood become angry.

2: to cause, by reason of stupidity, ineptitude, malice, or uncaring, the blood of another to become angry.

3: to think certain thoughts or participate in any such behaviour that would tend to cause your own blood to become angry.
"I don't read newspapers, they anger up the blood."
by goodcop8 October 27, 2007
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