The sale of items in large quantities. Typically, wholesale is for retailers who wish to purchase items at a lower price to sell them for a higher price. see profits
Upon arriving at the website, Ol' Johny realised that he could not purchase his desired item, as it would require the purchase of other items because the site only accepted "wholesale"
a slang term often used in the glenbeigh region. It can take on a variety of different meanings depending on the situation. Most often it means "constantly" or "yes"
While our lifespan is the number of years we will live, our healthspan is the number of healthy years we will have and our sexspan is is the number of years we will continue to be healthy enough to continue having an active sex life.
A lighthearted reaction upon receiving disappointing news of some sort. Usually something that isn't a particularly a big deal, esp. when it primarily affects someone else - sort of a mild schadenfreude. Sometimes doubled or tripled, and possibly said in a sing-songy voice for added comedic effect to imitate a muted trumpet, which is how the meme originated.