Go to prison. Originates from the fact that convicts from New York City would be sent up the Hudson River to Ossining State Prison ("Sing Sing").
"In 1959, Genovese was sent up the river for drug trafficking."
by JDonnelly November 16, 2006
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A term used for when someone kills themself by cutting vertically up their arm
What happened to that girl?

She took a trip up the river.
by dietcokegirl May 15, 2015
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South Australian term for going to Mannum, South Australia.
Bloke 1: What are you doing this weekend?
Bloke 2 : Going up the river.
Bloke 1: Heaps good.
by Deftercanine April 2, 2011
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Anal sex whilst the receiving partner is suffering a bout of diarrhoea.
Jonathan 'jay-kay' Kell Going up the river Thames
4 minutes ago via Text message · Comment · Like
by falolout August 4, 2010
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1. Convicting O. J. Simpson.
2. Ejaculating inside someone.
This is lasting too long... I'm sending juice up the river!
by monsignor morpheus August 5, 2016
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Fill a solo cup with beer. Take a deck of 52 cards. Two people each draw a card. The person with the highest number (1 - 13) doesn't have to do anything. The person who draws the lowest card has to chug the beer for the amount of seconds equal to the difference in the cards. (example: Anna draws a four, Patty draws a nine). Anna has to chug beer for five seconds (use a stop watch). If you draw a joker, the person who drew the joker has to chug for three times the amount of the other card (example: Patty draws a joker, Anna draws a six. Patty has to chug for 18 seconds). The goal of the game is to finish the entire deck of 52 cards in the shortest amount of time. Can be played with multiple teams going against each other.
Hey Anna let's play Up The River Down The River tonight...

Okay Patty. It's on. Bring all your friends...
by indianna500 June 10, 2009
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