The city of Syracuse, New York.

Nick name used by Syracuse natives when referencing their hometown and/or Syracuse University.
Did you watch the Cuse game last night?
by John Stamos April 3, 2005
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Familiar, endearing name for Syracuse, NY. Used by people of Upstate, New York.
It's snowing in Cuse again.
by Valery Drake March 4, 2005
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A word used by illiterate people who cannot spell "cousin".
Michelle Foord: "Thank you to my cusing for makeing me a lush curry agine"
by Some Dude On The Internet November 27, 2013
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