THTR Share definition Flag When texting or messaging a friend who doesn't respond for a period of time because of taking a lot of drugs, stand for Too High To Reply. Nick: I couldn't get a hold of Matt. Josh: Is he THTR? THTR by nmjohn April 20, 2008 0 0 Get merch Get the THTR mug. Buy Now — $32.95 See more merch
