When a bands debut album is a hit, and any subsequent album is shit in relation to it. New albums released by bands suffering from Strokes Syndrome do not themselves necessarily have to be shit ... but chances are that they are.

Etymology: the phrase Strokes Syndrome comes from the band The Strokes, whose debut album Is This It was an undisputed masterpiece. As such, all their later albums, although average to good, had the appearance of being disappointing.
I was able to diagnose Alt J with Strokes Syndrome just minutes into the first track of their new album. It was a bloodflood.
by Bird345 September 16, 2014
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A book, television show or movie which seemed to be awesome when seen as a child but turn out to be unbearably shitty as an adult.
1. I tried to watch Voltron the other day. What a terrible show! I can't believe we watched that shit back in the day. Talk about Different Strokes Syndrome.

2. Jonathan Livingston Seagull gave me a total "I'm special" hard-on when I was 13. Due to Different Strokes Syndrome, I couldn't make it through the first chapter as an adult.
by Robot Loves Zombie May 13, 2010
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