Scrotalfluff Share definition Flag The material (or fluff) that accumulates on the bottom of your scrotum. This is the same concept as belly button lint. My girlfriend was going down on me and noticed I had a load of scrotalfluff. Scrotalfluff by tap3w0rm_ May 12, 2010 0 0 Get merch Get the Scrotalfluff mug. Buy Now — $32.95 See more merch