Psycho Maniac Syndrome Share definition Flag Psycho Maniac Syndrome or PMS is the time of the month where women get extra crazy and bitchy Why is Debby such a bitch lately? She's having Psycho Maniac Syndrome. Psycho Maniac Syndrome by doctordomealittle August 22, 2009 0 0 Get merch Get the Psycho Maniac Syndrome mug. Buy Now — $32.95 See more merch