Pepe Hands 

A very sad or feels bad moment

Tyren doesn’t have a dad that’s pepe hands

Pepe Hands by Twhock September 13, 2019

PepeHands 

A twitch emote used at the end of a phrase to indicate sadness and/or depression or to indicate the prior phrase was indicative of that.

"I can't believe I still play *game*, I have no life PepeHands."
"That was the worst luck I've ever had PepeHands"

PepeHands by Bone Hurting Juice June 8, 2018

Snail Pepehands 

snail is a pleb in admiral bulldog who imprison because of playing music “becalmed” in the game of sea of thieves.

you can use the sentence everytime you hear “becalmed” soundtrack anywhere or you see uncausedsnail85 in admiral bulldog’s stream
“snail pepehands his only crime was music pepehands”

Snail Pepehands by peppapog March 13, 2021

PEPEHANDS 

When one is very sad boi

Bro, just drop a nude and she said "small" pepehands.

PEPEHANDS by Monster energy gives me anxiet May 9, 2020