Slang for heroin. AKA number four heroin. Its etymology refers to the last of a 4-step purification process in which heroin is purified into a white fluffy powder.
To ejaculate; to go number four means to ejaculate, whether from a penis or a vulva. To explain the structure; number one means to urinate, number two denotes defecation, number three refers to vomiting, and number four equates to ejaculation.
Mike: Holy shit! There's Nova!
Zack: Over there?
Mike: Oh fuck! I think I'm about to go number 4! I'll be right back!
Zack: Oh, ok then!
Nova: Hi Zack! Where's Mike, he was with you a minute ago, wasn't he?
Zack: Oh yeah, he just went number 4, that's all!