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That unnerving feeling when something has gone horribly wrong while doing work and your anus tightens up in a flinching and constipated way. It's a form of panic attack when you realise your life / career just ended and you go into a wild panic to try rectify the situation before you get found out.
Boss: While you're updating all the systems, if it goes pear shaped, don't have a nipsy twitch, just get it fixed!

or

Worker: I hit the red button instead of the green one and suddenly felt my nipsy twitch.
by the_minidude June 17, 2014
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