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The small flakes of dried, dead skin, left behind by (usually chaffed) testicles in underwear.

"Nadruff" can also be a mixure of debris such as chad particles, semen, urine and other bodily /non bodily fluids that have dried out and crusted off.
*GIRL* licks guys testicles/nut sacks
*GIRL* Omg i got something in my mouth from your balls and its kind of chewy.
*GUY* Oh shit i must have nadruff!.

"BRO my balls are kinda itchy" , ...
"Haha, last time my nuts were itchy i went to have a wank an seen that there was "Nadruff" in my boxers!"
Nadruff by Tease Nismo September 25, 2020
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Dead flakey skin often found on your Nans collar or favourite armchair.
Fuck me nan, your covered in Nandruff, go and clear of you skanky old bag
Nandruff by MalcomShiddarse December 4, 2023
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