When someone's really uptight and generally being a humorless or overstudious person, you'd say this to them to indicate that they need to relax and take themselves less seriously sometimes. A kinder alternative to get over yourself.
"Why would you play that game? It's so violent and misogynistic!"
"Wow, what are you my mom? It's just good mindless fun, loosen your collar. Damn!"
Short-hand for the word floccinaucinihilipilification, meaning the estimation of something as valueless (encountered mainly as an example of one of the longest words in the English language).
Precedes or follows either a gratuitously disrespectful or honest remark, originated in New York City. Used in similar fashion to "no offense" or "to be honest," interchangeably.
Ya mans is wild buns, respectfully. Respectfully he's washed.
After school, The Modells on Jamaica Ave was active. Respectfully.