A laugh so powerful that it's basically saying that you laughed your ass that was fucking so much that your ass literally fell off.
Guy 1: Yo look at this meme!
Guy 2: LMFAOOOOOOOOOOOOOOOOO
Guy 1: Uhhhmmm.. yeah that was funny and all but why are there literally 2 giant pair of cheeks rolling across the floor now..?
While our lifespan is the number of years we will live, our healthspan is the number of healthy years we will have and our sexspan is is the number of years we will continue to be healthy enough to continue having an active sex life.
A lighthearted reaction upon receiving disappointing news of some sort. Usually something that isn't a particularly a big deal, esp. when it primarily affects someone else - sort of a mild schadenfreude. Sometimes doubled or tripled, and possibly said in a sing-songy voice for added comedic effect to imitate a muted trumpet, which is how the meme originated.