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'Jacking up' is the state in which a person/hobo/fugitive finds himself somehow getting involved with injecting heroin, a really bad drug, also a really stupid way of ingesting a drug. 'Jacking up' is sometimes referred to as 'stabbin' da veins'
Jalentine posted a photo of himself 'jacking up' which means he is a real badboy and he also got a tattoo and now he is fell over because he did too much heroin.
by MC BeeStealer February 11, 2016
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To have a lot of something whether it be materially or people and wanting some more of that
by Christia January 31, 2004
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Watching '24'.
"Where's Toby?"

"He's not coming out; he's too busy jacking up. That's 19 hours straight, man. I think he's got a problem.."
by Chandra42 September 03, 2008
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