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Isot stands for Island in the Sea of Time. It references a novel where an island in relatively recent times is taken from it's time and place, and placed in the distant past, creating an alternate history. The acronym is popular on the alternate history forum.
What if Darth Vader were ISOTed into Anakin just after his nightmares about his mother started?
isot by JunAhrkSonaak November 18, 2017
Related Words

Isoscuse 

An excuse able to be executed as the result of The Virus.
I couldn’t buy a present because, you know, pandemic = Isoscuse
Sorry I can’t return your <insert borrowed item> because I can’t leave the house = Isoscuse.
I can’t take the dog for a walk because I can’t find a face mask to fit him = Isoscuse
Isoscuse by El Asto April 8, 2020

Isosceles Lock 

69 performed with three participants rather than two.

via Achewood: May 5, 2004
In a three-way, nobody sits around bored if you employ the Isosceles Lock.
Isosceles Lock by Gimpson May 3, 2004

Isosceles 

Popular UK YOUTUBER and part time shape and beta squad member isosceles (Aj shabeel) rumour has it he loves watching mr maker on CBeebies with kingkennytv
Some random waffler:Oi fam it's isosceles Whats the Pythagoras theorem

Niko: the schmuck who knows it lives in waffle town his name is camera man George

Niko
Isosceles by The waffler NDL 69 January 1, 2020

Isotoners 

A outdoor rubber glove, used for gardening and yard work. The brand of gloves OJ couldn't fit on his hands during his murder trial.
Joe: I'm thinking of getting these isotoners to do some yard work

Bob: Good idea, plus if you kill someone and they get wet they'll shrink and you'll be acquitted.
Isotoners by Randyt13 June 22, 2013
Each element has many versions that contain a different number of neutrons in the nucleas. Each different version of the element is called an isotope.
Carbon-13 is and isotope of Carbon
Isotope by PrivateDonut February 10, 2005