Top definition
A person held in low regard.

A person who is worthless.

Variant of dumb fuck or little fuck (guppies are little) or just plain fuck used as a noun.

Possibly of jail or penetentiary origin from the Eastern United States.
That little "guppy fuck" don't know nothin'.

Wait till I catch that little "guppy fuck" alone...

That guppy fuck of a doctor won't give me any drugs!
by The Nedster March 02, 2011
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