Guasappe Share definition Flag An incredibly latino sounding way to say the words 'What's up' as one word. "Guassape?""Dafuck you trying to say?""Guasappe.""Oh. Not much, man." Guasappe by Sr. Guzman January 9, 2015 0 0 Get merch Get the Guasappe mug. Buy Now — $32.95 See more merch