guf 

Gross Upper Fup, the next step beyond the first roll of fat above the female genitalia.

Her fup will become a guf, if she does not regulate her eating and get some exercise.

guf by JWJ September 15, 2008

GUF 

GUF - Giant Ugly Face

Wow George, I never realized your girlfriend had such a GUF.

GUF by drshogie January 20, 2011

Guf 

Someone or somthing that is annoying you at the time.

"she's a stupid bitch"
"yeah, what a guf"

Guf by Meg October 30, 2004

GUF 

A good, uncomplicated fuck.

Ughh, what a day. I really need a GUF, right now.

GUF by Daezed June 19, 2014

Guf 

Going until failure. Hitting as many reps as possible while lifting weights

I’m about to GUF on bench right now!

Guf by Ad25 February 14, 2019

Guf 

Verb: Guffed
1. Stands for

Gay
Ugly
Fat
2. A person that eats sand and shoves it up their nose
3. Someone that eat shit out in their backyard

E.g.

1. Ew get away from me you guf person
2. Go back to the desert you guf

Guf by By Ella the amazing biotch 😻 November 29, 2021

Guf 

A physical interaction from someone, or something, that is intended to platonic, though in rare cases can be romantic

"Man, Sasha just gave me a guf!"

Guf by ANC13NT_R1C3 May 8, 2022