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Gross Upper Fup, the next step beyond the first roll of fat above the female genitalia.
Her fup will become a guf, if she does not regulate her eating and get some exercise.
by JWJ August 29, 2006
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Someone or somthing that is annoying you at the time.
"she's a stupid bitch"
"yeah, what a guf"
by Meg October 30, 2004
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Going until failure. Hitting as many reps as possible while lifting weights
Iโ€™m about to GUF on bench right now!
by Ad25 February 14, 2019
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