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A fanterm used to describe the yaoi (boyxboy) pairing of Francis (or Francois in some cases) Bonnefoy and Alfred F Jones, from the anime and manga series Axis Powers Hetalia. They are also called or known as the Food Lovers pair. Not as popular as some of the other fanservices, but still enough to have a multitude of fanfics and fanart. The two names are the human names of the humanized countries they personify, Francis being France and Alfred being America (USA).

The "Fr" part stands for France and the "US" for America.

Most of the time, when the pairing is seen, France is the seme, or dominant one in the relationship while America is the uke, the submissive one. But, in rare occasions, the roles can be switched and France would be the uke under America. Though it is not found as much, either way are popular among the many fans that support the pairing.
I love that FrUS fanfic you showed me the other day!

Those FrUS pics were so cute!!

FrUS is my favorite pairing in Hetalia.
FrUS by Francypants_Bonnefoy February 3, 2012
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It’s a bus slash Ferrari. It is half bus, half Ferrari.
What would you do if you were run over by a frus
Frus by Jings June 24, 2019
Related Words
A tall and bald man. Lifts heavy weights and drives a red Honda Civic.
FRUS by regular diamonds November 24, 2020
A rare ship found in the Countryhuman fandom and the Hetalia fandom, the two countrys being France and the US. How this ship was created, nobody knows.
"I wish there was more FrUs fanfics on ao3."
FrUs by here._.to._.go May 4, 2022
It is so cold outside, I think have a frussy!
Frussy by Tracy Gonzalez December 13, 2017
Frusky is a UHCF (Ultra Hardcore Factions) Minecraft server. This server consists of eBoys and eGirls.
Hey man! Want to play some Frusky together to slay some eGirls in-game?
Frusky by eBoy77 August 26, 2020

John Frusciante 

Former guitar for the Red Hot Chili Peppers, only one of the select few who are truly all for the music.
"Have you read that book that John Frusciante wrote? I think it was called the bible or some-shit"
John Frusciante by Old Mate October 29, 2012