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An extinct species of large wolves that lived during the Ice Age, and a name for women who are 70 years and older who go hunting for younger men. While Puma covers the age range of late '20s to early '30s, Cougar for late '30s and early '40s, and Arctic Fox for post-menopause, Dire Wolf covers the age range of the truly elderly.
There's a Dire Wolf checking me out at the bar, maybe she'll buy me some drinks with her social security money.

I hooked up with a Dire Wolf last night, and I think I broke her hip.
Dire Wolf by mavra_chang June 30, 2010
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Jasperian Dire Wolf 

The 'Jasperian Dire Wolf' is a closed species for anthropomorphic characters, owned by @DireOpportune.
This species is a type of Dire Wolf that is taller then others, pointy ears and tends to always have the attitude of a dreadful man.
The Jasperian Dire Wolf is a wolf of great size and anger.
Jasperian Dire Wolf by J-Pyro February 27, 2020
They're like wolves... but dire
Prince of Canada:" You know what a Direwolf is, right? They're like wolves, but they're DIRE"
Direwolf by Spengatron August 20, 2017
The civilian counterpart to the sheepdog; one who protects the flock from wolves because they are fond of the sheep.
"What happened with that terrorist?"

"Nothing! A direwolf drew on him and the guy surrendered to the authorities."
direwolf by Jim Locke23 September 8, 2019
Large and intelligent form of wolf from the Song of Ice and Fire series by George R.R. Martin, found beyond the Wall north of Winterfell, and kept as pets by the children of Lord Eddard Stark, Warden of the North and Lord of Winterfell.
The direwolf's massive size pannicked the horses into a stampede.
Direwolf by Watchers November 21, 2004
DireWolf is my favorite animal.
DireWolf by LokiWolfHeathins October 19, 2018
noun A character or item that ends up useless.
Did you watch X-Men: Apocalypse? Turns out Jubilee was just another direwolf.
Direwolf by sir kiko May 29, 2016